A provider-reviewed low-dose naltrexone program with individualized prescribing and pharmacy dispensing when appropriate.

Low-Dose Naltrexone (LDN) Program

The Invyncible Low-Dose Naltrexone Program gives adults access to an evaluation by a licensed medical provider who determines whether LDN may be appropriate based on their health information.

A prescription is not guaranteed. If prescribed, the medication is dispensed by an independent licensed pharmacy and shipped directly to the patient. No subscription or long-term commitment is required.

Understanding Low-Dose Naltrexone

Naltrexone is an opioid-blocking medication that is FDA-approved at standard doses for specific alcohol- and opioid-related indications.

Low-dose naltrexone, commonly called LDN, refers to naltrexone prescribed at doses below its standard FDA-approved dosing. LDN is prescribed off-label, meaning FDA has not approved naltrexone at these lower doses for the condition or goal for which it may be prescribed.

Research examining LDN for various off-label uses remains limited and continues to evolve. LDN has not been established as a treatment for appetite control or weight loss, and no specific result is guaranteed.

Why Patients Choose This Program

Patients may choose the Invyncible LDN Program because it provides:

• Evaluation by a licensed medical provider

• Individualized prescribing and dosing

• At-home oral administration when prescribed

• Pharmacy-dispensed medication

• No required subscription

• Access to patient support

Your provider determines whether LDN is appropriate and establishes the formulation, dose, administration schedule and treatment duration.

Important Opioid Warning

Naltrexone interacts with opioid medications and can block their effects or cause sudden withdrawal in someone who is physically dependent on opioids.

Tell your provider if you currently use or have recently used:

• Prescription opioid pain medication

• Tramadol

• Methadone

• Buprenorphine

• Opioid-containing cough or diarrhea medication

• Any illicit opioid

Do not begin LDN until your provider determines that it is safe. Tell surgeons, dentists and emergency healthcare professionals that you take naltrexone because it may affect pain-management options.

Never take additional opioids in an attempt to overcome naltrexone’s blocking effects. Doing so may cause serious injury, overdose or death.

Possible Side Effects

Possible side effects may include:

• Nausea or stomach discomfort

• Headache

• Dizziness

• Fatigue

• Vivid dreams or sleep disturbances

• Nervousness or mood changes

• Changes in liver enzymes

• Allergic reactions

This is not a complete list. Contact your healthcare provider about persistent or concerning symptoms. Seek immediate medical attention for difficulty breathing, facial or throat swelling, severe abdominal pain, yellowing of the skin or eyes, dark urine or other serious symptoms.

Tell your provider about all medical conditions, medications, supplements and allergies, including any history of liver or kidney problems and whether you are pregnant, planning to become pregnant or breastfeeding.

Compounded Medication Notice

LDN dispensed through this program may be compounded pursuant to an individual patient prescription. Compounded medications are not FDA-approved and have not been reviewed by FDA for safety, effectiveness or quality.

Ingredients, strength, dosage form, storage requirements and availability may vary by prescription, pharmacy and state.

Our Role

Invyncible provides administrative and technology support for independently owned affiliated medical practices. Medical evaluations and prescribing decisions are made solely by licensed medical providers. Medications are dispensed by independent licensed pharmacies.

Invyncible does not practice medicine, compound medications or dispense prescriptions.